Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.

Haematologica, Early view

C O’Brien, T Ling, JM Berman, R Culp-Hill, JA Reisz, V Rondeau, S Jahangiri, J St-Germain, V Macwan, A Astori, A Zeng, JY Hong, M Li, M Yang, S Jana, F Gamboni, E Tsao, W Liu, JE Dick, H Lin, A Melnick, A Tikhonova, A Arruda, MD Minden, B Raught, A D’Alessandro, CL Jones

 

Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax+ Azacitidine by Targeting Fatty Acid Desaturases 1 and 2.

Metabolites, 13 (4), 467.

R Culp-Hill, BM Stevens, CL Jones, S Pei, M Dzieciatkowska, M Minhajuddin, CT Jordan, A D’Alessandro

 

The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoeitic stem and progenitor cells to maintain stemness.

Nature Cell Biology, 24, 872-884.

GE Thomas, G Egan, L Garcia-Prat, A Botham, V Voisin, PS Patel, FW Hoff, J Chin, B Nacmias, KB Kaufmann, DH Khan R Hurren, X Wang, M Gronda, N MacLean, C O’Brien, RP Singh, CL Jones, SM Harding, B Raught, A Arruda, MD Minden, GD Bader, R Hakem, S Kornblau, JE Dick, AD Schimmer

 

Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors.

Experimental Hematology, 12, 24-34.

C Zhou, R Uluisik, JW Rowley, C David, CL Jones, CD Scharer, L Noetzli, MH Fisher, GD Kirkpatrick, K Bark, JM Boss, CJ Henry, EM Pietras, J Di Paola, CC Porter

 

NOX2: determinant of acute myeloid leukemia survival.

Haematologica, 10 (11), 2530-2531.

CL Jones

 

The STAT3-MYC Axis Promotes Survival of Leukemia Stem Cells by Regulating SLC1A5 and Oxidative Phosphorylation.

Blood. 139 (4), 584-596.

ML Amaya, A Inguva, S Pei, CL Jones, A Krug, H Ye, M Minhajuddin, A Winters, SL Furtek, F Gamboni, B Stevens, A D'Alessandro, DA Pollyea, P Reigan, CT Jordan

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia.

Blood Cancer Discovery. 2 (3), 266-287.

D Yan, A Franzini, AD Pomicter, BJ Halverson, O Antelope, CC Mason, JM Ahmann, AV Senina, NA Vellore, CL Jones, MS Zabriskie, H Than, MJ Xiao, A van Scoyk, AB Patel, PM Clair, WL Heaton, SC Owen, JL Andersen, CM Egbert, JA Reisz, A D’Alessandro, JE Cox, KC Gantz, HM Redwine, SM Iyer, JS Khorashad, N Rajabi, CA Olsen, T O'Hare, MW Deininger

 

 

Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors.

Cell Stem Cell. 3 (4), 378-393.

CL Jones, A Inguva, CT Jordan

 

 

Enriching for human acute myeloid leukemia stem cells using reactive oxygen species-based cell sorting.

STAR Protocols. 2 (1) 100248.

BM Stevens, C O’Brien, CT Jordan, CL Jones

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.

Cell Stem Cell. 27 (5), 748-764.E4.

CL Jones, BM Stevens, DA Pollyea, R Culp-Hill, JA Reisz, T Nemkov, S Gehrke, F Gamboni, A Krug, A Winters, S Pei, A Gustafson, H Ye, A Inguva, M Amaya, M Minhajuddin, D Abbott, MW Becker, J DeGregori, CA Smith, A D’Alessandro, CT Jordan

 

 

Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells.

Nature Cancer. 1, 1176-1187.

BM Stevens, CL Jones, DA Pollyea, R Culp-Hill, A D’Alessandro, A Winters, A Krug, D Abbott, M Goosman, S Pei, H Ye, AE Gillen, MW Becker, MR Savona, C Smith, CT Jordan

 

 

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.

Cancer Discovery. 10 (4), 536-551.

S Pei, DA Pollyea, A Gustafson, BM Stevens, M Minhajuddin, R Fu, KA Riemondy, AE Gillen, RM Sheridan, Jihye Kim, JC Costello, ML Amaya, A Inguva, A Winters, H Ye, A Krug, CL Jones, B Adane, N Khan, J Ponder, J Schowinsky, D Abbott, A Hammes, JR Myers, JM Ashton, T Nemkov, A D'Alessandro, JA Gutman, HE Ramsey, MR Savona, CA Smith, CT Jordan

IL12 Abrogates Calcineurin-Dependent Immune Evasion during Leukemia Progression.

Cancer Research. 79 (14), 3702-3713.

JL Rabe, L Gardner, R Hunter, JA Fonseca, J Dougan, CM Gearheart, MS Leibowitz, C Lee-Miller, D Baturin, SP Fosmire, SE Zelasko, CL Jones, JE Slansky, M Rupji, B Dwivedi, CJ Henry, CC Porter

 

 

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II.

Blood. 134 (4), 389-394.

CL Jones, BM Stevens, A D’Alessandro, R Culp-Hill, JA Reisz, S Pei, A Gustafson, N Khan, J DeGregori, DA Pollyea, CT Jordan

 

 

The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML Cells.

Cancer Discovery. 9 (7), 910-925.

T Nechiporuk, SE Kurtz, O Nikolova, T Liu, CL Jones, A D'Alessandro, R Culp-Hill, A d'Almeida, SK Joshi, M Rosenberg, CE Tognon, AV Danilov, BJ Druker, BH Chang, SK McWeeney, JW Tyner

 

 

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.

Cell Reports. 27 (1), 238-254.E6.

B Adane, H Ye, N Khan, S Pei, M Minhajuddin, BM Stevens, CL Jones, A D’Alessandro, JA Reisz, V Zaberezhnyy, M Gasparetto, T Ho, KK Kelly, JR Myers, JM Ashton, J Siegenthaler, T Kume, EL Campbell, DA Pollyea, MW Becker, CT Jordan

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

Cancer Cell. 34 (5), 724-740.E4.

CL Jones, BM Stevens, A D’Alessandro, JA Reisz, R Culp-Hill, T Nemkov, S Pei, N Khan, B Adane, H Ye, A Krug, D Reinhold, C Smith, J DeGregori, DA Pollyea, CT Jordan

 

 

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Nature Medicine. 24 (12), 1859-1866.

DA Pollyea, BM Stevens, CL Jones, A Winters, S Pei, M Minhajuddin, A D'Alessandro, R Culp-Hill, KA Riemondy, AE Gillen, JR Hesselberth, D Abbott, D Schatz, JA Gutman, E Purev, C Smith, CT Jordan

 

 

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes.

Nature Communications. 9, 3694.

BM Stevens, N Khan, A D'Alessandro, T Nemkov, A Winters, CL Jones, W Zhang, DA Pollyea,  CT Jordan